Credit hours
In-class work per week |
Practice per week |
Credits |
Duration |
Total |
2 |
2 |
8 |
15 weeks |
120 hours |
Instructor
Claudia Barros Monteiro Vitorello
Maria Carolina Quecine Verdi
Objective
Microorganisms are certainly the most abundant and diverse group on earth. They are responsible for a great variety of natural and biotechnological processes of critical importance to men and their survival. Many microorganisms are model organisms for various studies. Thus, the understanding of its genetics is indispensable for research in molecular and genomic biology, as well as for its use in various biotechnological processes.
Content
Introduction to genetics of microorganisms. Cell cycle and classification of prokaryotes and eukaryotes. Mating type system in filamentous fungi. Communication between microorganisms: quorum sensing in bacteria. Studies of genomic evolution in prokaryotes and eukaryotes. Gene and epigenetic regulation in microorganisms. The role of structural RNAs in the microbial world. Mobile elements in microorganisms: transposons, gene islands and horizontal gene transfer. Metagenome and discoveries of new microbiomes and genes. New applications of microorganism genetics in recombinant DNA technology and agriculture. Directed evolution and synthetic biology applied to microbiology. Acquired immunity in prokaryotes and the emergence of the CRISPR-Cas9 technique. Special topic: viruses and their organization.
Bibliography
Microbiologia. Ed. G. J. Tortora, B. R. Funke & C. L. Case. Artmed, Porto Alegre-RS. 2012. 934 pp. ISBN: 8536326069 9788536326061.
Cellular and Molecular Biology of Filamentous Fungi. Ed. K. A. Borkivich & D. J. Ebbole. ASM Press, Washington, DC. 2010. 788 pp. ISBN 9781555814731.
Biologia Molecular e Genética Bacteriana. Ed. M. V. Marques. Sociedade Brasileira de Genética, Ribeirão Preto-SP. 2012. 348 pp. ISBN: 9788589265164.
Fundamentals of Molecular Virology. Ed. N. H. Acheson. John Wiley E Text Sons Inc, New Jersey. 2011. 528 pp. ISBN: 9781118214893.
Bioinformatics and Functional Genomics. Ed. J. Pevsner. Wiley-Bloackwell, New Jersey. 2009. 951 pp. ISBN 9780470085851.
The evolution of the genome. Ed. T. Ryan Gregory. Elsevier, Amsterdam. 2005. 740 pp. ISBN: 9780123014634.
The origins of genome architecture. Ed. M. Lynch. Sinauer Associates, Sunderland, MA. 2007. 494pp. ISBN-10: 0878934847/ ISBN-13: 9780878934843.
Microbial Diversity and Bioprospecting. Ed. A. T. Bull. ASM Press, Washingtin, DC. 2004. 496 pp. ISBN-10: 1555812678/ ISBN-13: 9781555812676.
Microbial Evolution: Gene Establishment, Survival, and Exchange. Ed. R. V. Miller & M. J. Day. ASM Press, Washington, DC. 2004. 374 pp. ISBN: 1555812716.
Methods for General and Molecular Microbiology. Ed. C.A. Reddy, T.J. Beveridge, J.A. Breznak, G. A. Marzluf, T.M. Schimidt & L.R. Snyder. ASM Press, Washington, DC. 2007. 1069 pp. ISBN-10:1555812236/ ISBN-13: 9781555812232.
Scientific review articles from leading journals in the area for weekly reading