Course - detail

LGN5809 - Molecular Genetics


Credit hours

In-class work
per week
Practice
per week
Credits
Duration
Total
4
1
8
15 weeks
120 hours

Instructor
Daniel Scherer de Moura
Marcio de Castro Silva Filho
Maria Carolina Quecine Verdi

Objective
The major objective of the course is offer to the students the basic knowledge concerning molecular genetics and its association with the phenotype as well as with the evolution of living organisms. The cellular functions and cellular biological processes will be understood at a molecular level with a holistic vision based on genomic, transcriptomic, proteomic and metabolomics, data integration, system biology and new tools that support the molecular genetics research.

Content
Introduction and the cellular molecules; structure and function of proteins; the complex definition of gene and genomics; transcriptional regulation of gene expression; post-transcriptional regulation of gene expression; cellular signaling; RNA of interference; cellular cycle; gene edition, system biology

Bibliography
LODISH, F.H. et al. Molecular Cell Biology, 7 ed., 2012. ISBN-10 1-4292-3413-X, 973p. LEWIN, B. Genes XI. 11 ed., 2012. ISBN-10: 1449659853, 940p. VOET, D.; VOET, J.G., Biochemistry, 4 ed. 2010. ISBN-10 0470570954, 1520p.
LEHNINGER, A.L.; NELSON, D.L.; COX, M.M, Principles of Biochemistry, 6 ed. ISBN-10: 1429234148, 1100p.

Alberts, B.; Bray, D.; Hopkin, K.; Johnson, A.; Lewis, J.; Raff, M.; Roberts, K.; Walter, P. 2011. Fundamentos da Biologia Celular. 3ª Edição brasileira. Artmed, Porto Alegre.
Selected articles published in journals such as Annual Review of Genetics - Cell - Molecular Cell - Current Opinion in Cell Biology - Current Opinion in Plant Biology - Trends in Plant Sciences - Trends in Cell Biology - Genetics - Journal of Molecular Biology - Proceedings of the National Academy of Science, USA - Nature - Nature Genetics - Nature Cell Biology - Science - Nature Biotechnology - EMBO Journal - Plant Cell - Journal of Biological Chemistry - Molecular and Cellular Biology - Molecular Biology of the Cell - Journal of Cell Biology