Credit hours
In-class work per week |
Practice per week |
Credits |
Duration |
Total |
3 |
2 |
8 |
15 weeks |
120 hours |
Instructor
Severino Matias de Alencar
Objective
Offer biochemical knowledge necessary for the graduate student to identify and analyze the general
aspects of the structure and function of major macromolecules. Allow the student know and understand
the main metabolic pathways of biological systems, recognizing the importance of these routes as an
opportunity to understand the cellular processes that provide and transfer the material and energy
among living organisms.
Content
1) Chemical Structure, physicochemical properties and functions of molecules of biological interest; 2)
Membrane cell: composition and transport mechanisms; 3) Enzymes: factors affecting enzyme activity,
kinetics, inhibition and allosteric enzymes; 4) Metabolism of carbohydrates: glycolysis, pentose
phosphate pathway, gluconeogenesis, synthesis and degradation of glycogen; 5) Cellular respiration; 6)
Metabolism of lipids: oxidation of fatty acids, metabolism of ketone bodies, fatty acid synthesis and
triacylglycerides. Synthesis and degradation of cholesterol; 7) amino acid metabolism: protein
metabolism, essential and nonessential amino acids; 8) Nitrogen Excretion and fate of carbon skeletons;
9) Vitamins and coenzymes: physiological functions of vitamins and hydro soluble; structure and
biochemical function of the main coenzymes. 10) Integration and Metabolic regulation: control of
metabolic flux at the level of concentration of the substrate, effectors, products and cofactors; regulating
the level of enzymes, enzyme activity; regulating the hormonal level. molecular mechanisms of signal
transduction; 11) Nucleic acids: structure and function; DNA and RNA.
Bibliography
NELSON, David L.; COX, Michael M.. Princípios de bioquímica de Lehninger. 7 Porto Alegre: Artmed,
2019, 1278 p.
VOET, D. Bioquímica. Porto alegre: Artmed , 4a ed., 2015. 1481p.
BERG, J. M. Bioquímica. Rio de janeiro: Editora guanabara Koogan S. A., 2014. 1162 p.
ELLIOTT, W.H & ELLIOTT, D.C ELLIOTT. Biochemistry and Molecular Biology. Oxford: Oxford University
Press, 4ª ed., 2009, 568p.
MURRAY, R. K.; FIGUEIREDO, J.E.F.; VOEUX, P.L.; DORVILLÉ, L.F.M.; LEIPNITZ, G. Bioquímica Ilustrada
de harper. Porto Alegre AMGH, 2014. 818p.
SALWAY, J.G. Metabolism at a Glance. Blackwell Science, 1994. 96p.